Sensitivity Changes of Actinomyces Bovis to Penicillin and Streptomycin.
نویسندگان
چکیده
Actinomycosis in the human being is a chronic, suppurative disease resulting from infection with the fungus Actinomyces bovis. Prior to the advent of the sulfonamides and later penicillin and streptomycin, the prognosis of patients suffering from actinomycotic infections was not too promising. There are many reports in the literature concerning the succesful use of penicillin as a chemotherapeutic agent (Decker, 1946; Farris and Douglas, 1947), but there is little in the literature on the clinical use of streptomycin in the treatment of actinomycosis. Costigan (1947) and Jacobson and Cloward (1948) have reported success in using this antibiotic in these infections; however, Pulaski and Seeley (1948) reported a case of actinomycosis treated with streptomycin that failed to respond to therapy and that was associated with the development of a highly resistant organism. The etiological agent in this case, however, was Nocardia asteroides, an organism closely related to Actinomyces bovis, which is not frequently associated with actinomycotic infections. In view of the chronic nature of the disease, long therapeutic periods have been indicated with the time of treatment varying from 5 days (Costigan, 1947) to 1 year or longer (Emmons, 1938). Since there are a number of reports concerning the rapid development of bacterial resistance to the antibiotics, especially to streptomycin, in which Miller and Bohnhoff (1946) and Seligman and Wassermann (1947) report that resistance may attain a 2,000to 50,00()fold increase, it is well to consider the possibility that resistant strains of Actinomyces bovis may develop during a long therapeutic period.
منابع مشابه
Guide to the Classification and Identification of the Actinomycetes and Their Antibiotics
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عنوان ژورنال:
- Journal of bacteriology
دوره 57 5 شماره
صفحات -
تاریخ انتشار 1949